Ora Calibra® Ocular Redness Scales

Ora Calibra® Ocular Redness scales are precisely calibrated to provide confidence in study results. These advanced redness scales have been employed worldwide in clinical studies of dry eye disease, allergic conjunctivitis, bacterial conjunctivitis, and glaucoma (drug-induced redness).

Recent research by the Ora Institute, has led to the development of an analogous, disease-specific ocular redness scale representative of the redness that is associated with morning eye congestion for purposes of clinical research. The scale, which is simple for clinical use, and permits interval and ratio interpretations, is valid, reliable, and capable of discriminating between subjects of varying severity.

Many ophthalmic conditions share redness as a clinical sign, but the particular pattern of redness varies considerably across pathological conditions. The conjunctival, sclera, episcleral, and ciliary vessel beds are known to respond to different disease states through variations in color, location, pattern, and degree of redness. For redness secondary to episcleritis, bacterial conjunctivitis, and dry eye disease, vasodilation is relatively superficial and subject to movement. In the case of dry eye disease, redness presents as fine linear conjunctival and ciliary vessel dilation, while redness due to allergic conjunctivitis presents as a deep, violet red, with prominent sclera vessel involvement typically limited to the palpebral fissure. Moreover, because leakage is a significant component of allergic conjunctivitis, this type of redness often appears through a haze due to chemosis.

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